A look at the history, approaches, and new research of spatially fractionated radiation therapy.
History of Innovations in Medical Physics
A look at the history of Medical Physics, highlighting discoveries that have paved the way for innovation.
In honor of last week’s International Day of Medical Physics, we’re highlighting discoveries in physics that have paved the way for innovation in the field of medicine. This pioneering work has resulted in medical breakthroughs and the dawning of the field of medical physics.
Mechanics of the Spine by Giovanni Borelli, via Physicsmedica
The term Iatrophysics, meaning “physics applied to medicine,” was the original term for medical physics and referred mostly to the mechanical nature of the human body. Giovanni Borelli, a physicist dedicated to this topic, applied mathematics and physics to physiology and described the motion of the body using basic physics–contraction, center of mass, expansion, weight, and gravity–and analogies such as pulleys and scales in his book, which was published shortly after his death in 1679. (2) Today, his description of body mechanics are now known to be incorrect, but he was one of the first players in what would become known as medical physics.
The father of medical physics is arguably Jean-Noel Hallé. As a professor of medical physics at the School of Health in Paris in the late 18th century, his teachings focused on musculo-skeletal movement, which could in-part be described by physics. Hallé was the first to teach anything related to the use of physics in medicine and carried out investigations on breast cancer. (2)
The modern era of medical physics began in 1895 in Willhelm Roentgen’s laboratory. While working with a cathode ray tube, Roentgen noticed he could see a screen glow some feet away even after shielding the tube with cardboard. He knew this was not the effect of the cathode rays he was researching and called these new rays, “x-rays.” Roentgen took an x-ray image of his wife’s hand, the first x-ray image and what is probably the most recognizable x-ray in history. Roentgen circulated the image to colleagues, and the medical uses for “x”-rays became apparent. (3)
X-Ray Image of the Hand of Roentgen’s Wife, via NCBI
After the x-ray, there was a whirlwind of innovations and discoveries that would eventually, if not immediately, have medical use. The 1890s were an important year for medical physics. The first radiograph was taken on a battlefield. The first attempt at using x-rays for therapy was completed, and while this attempt to treat a stomach cancer failed, the failure did not inhibit future treatment efforts, which continued to rise in number.
Radioactivity was also discovered by Henri Becquerel. Both of these men would go on to win the Nobel Prize in physics for their landmark discoveries, with Roentgen the first ever to be awarded the prize in 1901. (3)
Left to Right: Henri Becquerel, Pierre and Marie Curie, and Wilhelm Roentgen. All four are Nobel Prize Recipients.
The Roentgen Society
These discoveries saw medical applications as early as 1901, when Becquerel reported being burned by a radioactive isotope, a result that led to the use of brachytherapy as a method of treating skin lesions. Once it was realized these new discoveries could inflict harm, the Roentgen Society was founded (now known as the British Institute of Radiology). They began cataloging injuries.
Clarence Dally assisted Edison in creating x-ray tubes and intensifying screens, and as a result of the unknown effects of the x-rays Dally developed cancer, which led to his death. His death became the first recorded one attributed to x-rays, with some calling him an “x-ray martyr.” (3)
Left: Thomas Edison looking at Clarence Dally’s hand under a flouroscope, via Smithsonian. Right: Clarence Dally’s Hand, via Vintage Everyday.
Discovery Application and the Rise of Hospital Physicists
Physicists were not yet commonly employed by hospitals until the 1930s when the number grew from 12 to about 40 in the UK, and continued rising as the applications of scientific discoveries increased. Such applications included:
- Teletherapy (starting in 1913), which attempted using an external radium beam with deeper penetration.
- William Coolidge’s improved x-ray tube (1913), which made it more reliable but still only capable of low kV outputs.
- Treating patients using megavoltage x-ray beam (1930s), which was possible due to improvements in accelerator technology influenced by World War II.
- Because of its higher energy, Cobalt-60 was used in teletherapy (1940s) and is still used in treatment today. (3)
One of the First MV Therapy Units, via NBCI
World War II’s Impact
Technological advancements came as a result of World War II and were readily adapted for medical use. For example:
- The klystron was created to improve radar during the war. Afterward, it was used to generate power for linear accelerators for patient treatment.
- Discoveries associated with the Manhattan Project led to the ability to generate radioisotopes in a quantity sufficient for therapy, which spawned the field of nuclear medicine. Treatment of the thyroid with iodine-131 was the first treatment to use a radioisotope.
- The effects of the atomic bomb were published in the Biological Effects of Ionizing Radiation (BIER) reports, which documented effects of ionizing radiation in humans and dose limits still used today.
The 1960s saw an explosion in medical imaging, including the creation of the gamma camera by Hal Anger, PET imaging, the use of x-ray CT in 1973 by Godfrey Hounsfield, and the development of MRI.
Over the past 25 years, the computer technology revolution has led to huge improvements in the quality of images and patient treatment. Continued innovation over the last decade has resulted in landmark improvements in radiation therapy such as adaptive therapy through imaging, use of MRI in conjunction with treatment, and use of automation and AI in therapy planning.
- This Month in Physics History; November 8, 1895: Roentgen’s Discovery of X-Rays
- The Origins of Medical Physics
- Physics and Medicine: A Historical Perspective
- Clarence Dally: The Man Who Gave Thomas Edison X-Ray Vision
- Henri Becquerel Biography
- Marie Curie the Scientist
- The Hand of Clarence Madison Dally, a Glassblower Who Worked With Thomas Edison, ca. 1900
Written by Carly Showalter
After working with Radformation as part of an industry cooperative while pursuing her medical physics MS at Hofstra University, Carly now contributes to the AutoContour team as a Clinical Data Analyst. In her free time she enjoys planning game nights with her friends and family.
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